Product Name	TFPI-2
Chinese Name	组织因子途径抑制剂-2抗体
Alias	tissue factor pathway inhibitor 2; TFPI-2; TFPI2; TFPI2_HUMAN; Tissue factor pathway inhibitor 2; Placental protein 5; PP5; TFPI 2; TFPI 2; TFPI2 PEN.
literatures	Specific References  (2)     |     SL1144R has been referenced in 2 publications. [IF=3.491] Hussam Ghoti. et al. Heparanase Level and Procoagulant Activity Are Increased in Thalassemia and Attenuated by Janus Kinase 2 Inhibition. Am J Pathol. 2020 Oct;190:2146  IHC ;  Mouse.   PubMed:32745462 [IF=0.34] Wang, Gui-Jun, et al. "Expression of tissue factor pathway inhibitor-2 in gastric stromal tumor and its clinical significance." Experimental and Therapeutic Medicine.  IHC-P ;  Human.   PubMed:24396436
Research Area	Cardiovascular  Cell biology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	25kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TFPI2: 135-235/235
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. It inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa, but it has no effect on thrombin. TFPI2 is specific to umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. This inhibitor contains three inhibitory domains. TFPI2 contains 3 BPTI/Kunitz inhibitor domains. Function: May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. Subcellular Location: Secreted (constituent of proteinaceous extracellular matrix) Tissue Specificity: Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. Similarity: Contains 3 BPTI/Kunitz inhibitor domains. SWISS: P48307 Gene ID: 7980 Database links: Entrez Gene: 7980 Human Omim: 600033 Human SwissProt: P48307 Human Unigene: 438231 Human 组织因子途径抑制因子(tissue factor pathway in hibitor, TFPI)是组织因子凝血途径的主要抑制因子， 组织因子途径抑制因子在诸如动脉粥样硬化，血管再狭窄，弥漫性血管内凝血DIC等方面，有一定的研究价值。 TFPI-2也称为胎盘蛋白-5(placenta protein 5，PP5)或细胞基质联合丝氨酸蛋白酶抑制物(matrix associated serine protease inhibitor，MSPI)。 TFPI-2是相对分子质量为:25KDa的丝氨酸蛋白酶抑制物, 由脉管系统细胞（endothelial cells、平滑肌细胞、成纤维细胞）合成，并沉积在这些细胞的Extracellular matrix里。TFPI-2为广谱丝氨酸蛋白酶抑制剂，能有效地抑制基质金属蛋白酶（MMP）、纤溶酶、胰蛋白酶、糜蛋白酶、组织蛋白酶等多种蛋白水解酶的活性，在维持Extracellular matrix（ECM）结构完整、抑制Tumour细胞浸润转移方面起着重要作用。TFPI-2分布广泛,在人肝脏、肾脏、心脏、骨骼肌等正常组织中有着高度表达,而在Tumour组织中也有一定程度的表达。
Product Picture	Tissue/cell: human colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩� for 20 min; Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(SL1144R) 1:200, overnight at 4掳C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(SL1144R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat colon tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37鈩� for 20 min; Incubation: Anti-TFPI-2 Polyclonal Antibody, Unconjugated(SL1144R) 1:200, overnight at 4掳C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (TFPI-2) Polyclonal Antibody, Unconjugated (SL1144R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody (sp-0023) for 20 minutes and DAB staining.

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