Product Name	DUOXA1
Chinese Name	双氧化酶成熟因子抗体
Alias	DOXA1_HUMAN; Dual oxidase activator 1; Dual oxidase maturation factor 1; duoxa1; NIP; Numb interacting protein; Numb-interacting protein; NUMBIP.
literatures	Specific References  (1)     |     SL11433R has been referenced in 1 publications. [IF=4.556] Yoon-Hee Cheon. et al. Dual Oxidase Maturation Factor 1 Positively Regulates RANKL-Induced Osteoclastogenesis via Activating Reactive Oxygen Species and TRAF6-Mediated Signaling. Int J Mol Sci. 2020 Jan;21(17):6416  WB,IF,IHC ;  Mouse.   PubMed:32899248
Research Area	Tumour  Cell biology  Neurobiology  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	38kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DUOXA1: 101-200/343 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	DUOXA1 is a 343 amino acid multi-pass membrane protein that belongs to the DUOXA family and exists as multiple alternatively spliced isoforms. Expressed almost exclusively in thyroid tissue, but also present in esophageal tissue, DUOXA1 interacts with NUMB and is thought to be essential for the maturation and transport of functional DUOX1 from the endoplasmic reticulum to the plasma membrane. The gene encoding DUOXA1 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. Function: May be required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX1. Subunit: May interact with NUMB. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Specifically expressed in thyroid gland. Also detected in esophagus. Similarity: Belongs to the DUOXA family. SWISS: Q1HG43 Gene ID: 90527 Database links:

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