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Product Name MC5 Receptor Chinese Name 黑素皮质素受体5抗体 Alias MC-2; MC2; MC5 R; MC5-R; MC5R; MC5R_HUMAN; Melanocortin 5 receptor; Melanocortin receptor 5. Research Area Tumour Cell biology Neurobiology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 37kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MC5 Receptor: 78-125/325 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The melanocortin family comprises the Alpha-, Beta- and Gamma- melanocyte stimulating hormones (MSH) and adrenocorticotrophin. The receptors for these hormones are seven-transmembrane G protein-coupled proteins that activate adenylyl cyclase. Five melanocortin receptors have been cloned and shown to exhibit different affinities and patterns of expression. MC1-R (MSH-R) is expressed in melanocytes and corticoadrenal tissue. MC2-R is the ACTH receptor and is expressed primarily in the adrenal cortex. MC3-R has been found in specific regions of the brain and is also expressed in placenta and gut. MC4-R is expressed primarily in brain, while MC5-R is expressed at low levels in most tissues.
Function:
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in the brain but not in the melanoma cells.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
P33032
Gene ID:
4161
Database links:Entrez Gene: 4161 Human
Entrez Gene: 17203 Mouse
Omim: 600042 Human
SwissProt: P33032 Human
SwissProt: P41149 Mouse
Unigene: 248145 Human
Unigene: 8003 Mouse
Unigene: 9673 Rat
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