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Product Name Relaxin 3 Chinese Name 松弛素3抗体 Alias H3; INSL 7; INSL7; Insulin like 7; Insulin like peptide 7; Insulin like peptide INSL7; Insulin like7; Insulinlike 7; Prorelaxin H3; Prorelaxin M3; REL 3; REL3; Relaxin 3; Relaxin 3 (H3); Relaxin 3 A chain; Relaxin 3 precursor; Relaxin3; RLN 3; RLN3; RXN 3; RXN3; ZINS 4; ZINS4; REL3_HUMAN. Research Area Tumour Cell biology Developmental biology Neurobiology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 3kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Relaxin 3 A chain: 119-135/142 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Relaxins are known endocrine and autocrine/paracrine hormones, belonging to the insulin gene superfamily. In the human there are three non allelic relaxin genes, RLN1, RLN2 and RLN3. RLN1 and RLN2 share high sequence homology. Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. It may have additional roles in enhancing sperm motility, regulating blood pressure, controlling heart rate and releasing oxytocin and vasopressin. The protein encoded by this gene is a member of the relaxin family. The active form of the encoded protein consists of an A chain and a B chain but their cleavage sites are not definitely described yet. It may play a role in neuropeptide signaling processes.
Function:
May play a role in neuropeptide signaling processes. Ligand for LGR7, relaxin-3 receptor-1 (GPCR135) and relaxin-3 receptor-2 (GPCR142).
Subunit:
Heterodimer of a B chain and an A chain linked by two disulfide bonds.
Subcellular Location:
Secreted.
Similarity:
Belongs to the insulin family.
SWISS:
Q8WXF3
Gene ID:
117579
Database links:Entrez Gene: 117579 Human
Omim: 606855 Human
SwissProt: Q8WXF3 Human
Unigene: 352155 Human
Product Picture Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-Relaxin-3 Polyclonal Antibody, Unconjugated(SL11412R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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