Product Name	Progestin Receptor Beta
Chinese Name	孕激素受体β（MPRβ）抗体
Alias	MPRB; C6orf33; LMPB1; Lysosomal membrane protein in brain 1; Membrane progestin receptor beta; mPR beta; MPRB; PAQR8; Progestin and adipoQ receptor family member 8; Progestin and adipoQ receptor family member VIII; MPRB_HUMAN.
literatures	Specific References  (3)     |     SL11410R has been referenced in 3 publications. [IF=17.173] Thomas Topilko. et al. Edinger-Westphal peptidergic neurons enable maternal preparatory nesting. Neuron. 2022 Feb;:  IHC ;  Mouse.   PubMed:35123655 [IF=4.26] Kasubuchi, Mayu, et al. "Membrane progesterone receptor beta (mPRβ/Paqr8) promotes progesterone-dependent neurite outgrowth in PC12 neuronal cells via non-G protein-coupled receptor (GPCR) signaling." Scientific Reports 7 (2017).  WB ;  Mouse.   PubMed:28701790 [IF=2.299] Gao XX et al. Effects of l-arginine on endometrial estrogen receptor α/β and progesterone receptor expression in nutrient-restricted sheep. Theriogenology. 2019 Jul 25;138:137-144.  IHC,IF&WB ;  ewe.   PubMed:31352175
Research Area	Cell biology  Neurobiology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat, Dog,  (predicted: Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Progestin Receptor Beta: 251-300/354 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The steroid progesterone induces the resumption of maturation in oocytes via a nongenomic pathway through binding to a novel membrane progestin receptor (mPR). This pathway inhibits adenylyl cyclase and reduces intracellular cAMP, and also activates mitogen-activated protein kinase to effect signal transduction pathways. Five distinct groups, designated Alpha, Beta, Gamma, Delta, comprise the mPR gene family. mPR Alpha, also designated progestin and adipo Theta receptor family member VII (PAQR7), consists of an extracellular N-terminus, an intracellular C-terminus and seven transmembrane domains. mPR Alpha is expressed in ovary, testis, placenta, uterus and bladder. mPR Beta, or progestin and adipo Theta receptor family member VIII (PAQR8), consists of eight putative transmembrane regions and an intracellular N-terminus that contains a leucine-rich motif. mPR Beta is a 354 amino acid protein expressed in brain and spinal cord. Both mPR Alpha and mPR Beta may be G protein-coupled receptors and may be involved in oocyte maturation. Function: MPRb (Membrane progestin receptor beta) is a steroid membrane receptor and binds progesterone. MPRb may be involved in oocyte maturation. MPRb is an integral membrane protein and is expressed in brain and testis. It belongs to the ADIPOR family. Subcellular Location: Cell Membrane. Multi-pass membrane protein. Note: Colocalizes with a lysosomal protein cathepsin D. Similarity: Belongs to the ADIPOR family. SWISS: Q8TEZ7 Gene ID: 85315 Database links: Entrez Gene: 85315 Human Entrez Gene: 74229 Mouse Entrez Gene: 316275 Rat Omim: 607780 Human SwissProt: Q8TEZ7 Human SwissProt: Q80ZE5 Mouse SwissProt: Q6AY03 Pig Unigene: 239388 Human
Product Picture	Sample: Lane 1: Hippocampus (Mouse) Lysate at 40 ug Lane 2: Medulld (Mouse) Lysate at 40 ug Lane 3: Hippocampus (Rat) Lysate at 40 ug Lane 4: Medulld (Rat) Lysate at 40 ug Primary: Anti-Progestin Receptor Beta (SL11410R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 46 kD Paraformaldehyde-fixed, paraffin embedded (Dog skin tumor); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Progestin Receptor Beta) Polyclonal Antibody, Unconjugated (SL11410R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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