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Product Name GNRHR2 Chinese Name 促性腺素释放激素受体2抗体 Alias GnRH IIR; Putative gonadotropin-releasing hormone II receptor; gonadotropin-releasing hormone (type 2) receptor 2; GnRH-II-R; Type II GnRH receptor; GNRR2_HUMAN. literatures Specific References (1) | SL11403R has been referenced in 1 publications.[IF=4.095] Ding H et al. Expression and regulation of GnRHR2 gene and testosterone secretion mediated by GnRH2 and GnRHR2 within porcine testes. J Steroid Biochem Mol Biol. 2019 Jun;190:161-172. WB&IHC-P ; Boar.Research Area Cell biology Neurobiology Signal transduction The cell membrane受体 G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Pig, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 33kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GNRHR2: 81-180/292 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Gonadotropin-releasing hormone (GnRH) is released in a pulsatile manner that varies with the reproductive cycle. This hypothalamic hormone is transported to the pituitary, where it binds to specific receptors and regulates the synthesis and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Localized to the cell membrane, GnRHR2 mediates its own receptor activity via association with G proteins, thereby activating a phosphatidylinositol-calcium second messenger system that regulates GnRHR2 function. GnRHR2 is thought to have potent antiproliferative effects on ovarian and endometrial cancer cells, suggesting a possible role in tumor suppression. Due to alternative splicing events, GnRHR2 is expressed as two isoforms.
Function:
Receptor for gonadotropin releasing hormone II (GnRH II). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Post-translational modifications:
Phosphorylated on the C-terminal cytoplasmic tail (Probable).
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q96P88
Gene ID:
114814
Database links:
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