Product Name	Somatostatin Receptor 2
Chinese Name	生长抑素受体2抗体
Alias	somatostatin receptor 2; Somatostatin receptor type 2; SRIF1; SS2R; SST2; SSTR2; SRIF-1; SS-2-R; SS2-R; SSR2_HUMAN.
literatures	Specific References  (4)     |     SL1138R has been referenced in 4 publications. [IF=6.792] Zhao D et al. PCB52 exposure alters the neurotransmission ligand-receptors in male offspring and contributes to sex-specific neurodevelopmental toxicity. Environ Pollut.2020 Sep;264:114715.  WB ;  Rat.   PubMed:32402713 [IF=2.22] Ruan, Ming, et al. "Attenuation of stress-induced gastrointestinal motility disorder by gentiopicroside, from Gentiana macrophylla Pall." Fitoterapia(2015).  WB ;  Rat.   PubMed:25936770 [IF=1.399] Jiuxiu Jiet al. The effect of miR‐10b on growth hormone in pituitary cells of Yanbian yellow cattle by somatostatin receptor 2. Anim Sci J . Jan-Dec 2020;91(1):e13420.  WB ;  yellow cattle.   PubMed:32618083 [IF=0.88] Sakai, Kosei, et al. "Alteration of somatostatin receptor 2 expression in canine mammary gland tumor." Journal of Veterinary Medical Science 0 (2015).  IHC-P ;  Dog.   PubMed:25985817
Research Area	Tumour  Developmental biology  Neurobiology  Apoptosis  G protein-coupled receptor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SSTR2: 211-320/369 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Somatostatin is a tetradecapeptide that is widely distributed in the body and is one of five receptor subtypes termed SSTr1-. These receptors function in the regulation of numerous phsiological processes such as the secretion of insulin, glucagon and growth hormone as wel as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptos are activated via sonatostatin secreted by nerve and endocrine cells. Somatostatin Receptor 2 (SSR2), along with SSR1, is expressed at the highest levels in the stomach and jejunum, cerebrum and kidney, respectively. Function: Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels. Subunit: The C-terminus interacts with SHANK1 PDZ domain. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Cerebrum and kidney. In lesser amounts in jejunum, colon and liver. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P30874 Gene ID: 6752 Database links: Entrez Gene: 6752 Human Entrez Gene: 20606 Mouse Entrez Gene: 54305 Rat Omim: 182452 Human SwissProt: P30874 Human SwissProt: P30875 Mouse SwissProt: P30680 Rat Unigene: 514451 Human Unigene: 454968 Mouse Unigene: 202974 Rat Unigene: 9929 Rat SSTR2的表达在Tumour的分布、发生和发展中起重要作用。目前主要用于Tumour方面的研究。

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