Product Name	Acetoacetyl-CoA synthetase
Chinese Name	脂肪酰辅酶A家族成员1抗体
Alias	Acetoacetyl-CoA synthetase; ACSF1; AACS; Acyl-CoA synthetase family member 1; Protein sur-5 homolog; AACS_HUMAN.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human AACS: 182-228/672
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis. Function: Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development Subcellular Location: Cytoplasm, cytosol Tissue Specificity: Highly expressed in kidney, heart and brain, but low in liver. Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. SWISS: Q86V21 Gene ID: 65985 Database links: Entrez Gene: 65985 Human Entrez Gene: 78894 Mouse Entrez Gene: 65984 Rat Omim: 614364 Human SwissProt: Q86V21 Human SwissProt: Q9D2R0 Mouse SwissProt: Q9JMI1 Rat Unigene: 656073 Human Unigene: 431573 Mouse Unigene: 9215 Rat

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