Product Name	RIMS3
Chinese Name	神经元突触膜胞外分泌调节蛋白3抗体
Alias	NIM 3; NIM3; Rab 3 interacting molecule 3; Regulating synaptic membrane exocytosis 3; Regulating synaptic membrane exocytosis protein 3; RIMS 3; RIMS-3; RIM 3; RIM3; RIM3 gamma; RIMS3; RIMS3_HUMAN.
Research Area	Cell biology  Neurobiology  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Zebrafish, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RIMS3: 21-120/308
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Rab 3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis and functions in an inhibitory capacity, controlling the recruitment and pooling of secretory vesicles at the plasma membrane. The Rim (Rab 3 interacting molecule) family of proteins (Rim1, Rim2, Rim3 and Rim4) are multidomain adaptors that regulate Rab 3 activity and sub-sequent neurotransmitter release. Rim3, also known as RIMS3 (regulating synaptic membrane exocytosis 3) or NIM3, is a 308 amino acid member of the Rim family. Localized to the synapse and to cell junctions, Rim3 contains one C2 domain and is thought to play an important role in the regulation of synaptic membrane exocytosis. Rim3, a protein that may be phosphorylated upon DNA damage, is expressed throughout the body with highest levels present in brain tissue. Function: RIMS3 belongs to a family of synaptic proteins that are essential for normal neurotransmitter release. It localizes primarily to neuronal dendrites and the postsynaptic densities, indicating that it may contribute to synapse transmission and plasticity. Subunit: Binds PPFIA3 (By similarity). Does not bind RAB3. Subcellular Location: Cell junction, synapse. Similarity: Contains 1 C2 domain. SWISS: Q9UJD0 Gene ID: 9783 Database links: Entrez Gene: 9783 Human Entrez Gene: 242662 Mouse Entrez Gene: 65025 Rat Omim: 611600 Human SwissProt: Q9UJD0 Human SwissProt: Q80U57 Mouse SwissProt: Q9JIR3 Rat

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