Product Name	Piccolo
Chinese Name	神经细胞突触蛋白PCLO抗体
Alias	ACZ; Aczonin; Brain-derived HLMN protein; DKFZp779G1236; KIAA0559; Multidomain presynaptic cytomatrix protein; PCLO; PCLO_HUMAN; Piccolo (presynaptic cytomatrix protein); Piccolo, mouse, homolog of antibody Pico; Presynaptic cytomatrix protein; Protein piccolo.
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	557kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Piccolo: 4951-5056/5056
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Piccolo is 1 component of the presynaptic cytomatrix. Bassoon is a large protein which is also found in the presynaptic compartments of rat brain synapses. Bassoon, along with Piccolo, is part of the ensemble of presynaptic proteins that are involved in orchestrating events at the nerve terminal. Bassoon is found in axon terminals of hippocampal neurons where it is highly concentrated in the vicinity of the active zone. Piccolo has a similar distribution and colocalizes with Bassoon in cultured hippocampal cells. Piccolo zinc fingers interact with the dual prenylated rab3A and VAMP2/ Synaptobrevin II receptor PRA. Bassoon may be involved in cytomatrix organization at the site of neurotransmitter release. The gene which encodes bassoon maps to human chromosome 3p21.31. The gene which encodes piccolo maps to human chromosome 7q21.11. Function: May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. Subunit: Interacts with RABAC1/PRA1, RIMS2 and profilin (By similarity). Subcellular Location: Cell junction, synapse. Note=Concentrated at the presynaptic side of synaptic junctions. Similarity: Contains 2 C2 domains. Contains 1 PDZ (DHR) domain. SWISS: Q9Y6V0 Gene ID: 27445 Database links: Entrez Gene: 27445 Human Entrez Gene: 26875 Mouse Entrez Gene: 56768 Rat Omim: 604918 Human SwissProt: Q9Y6V0 Human SwissProt: Q9QYX7 Mouse SwissProt: Q9JKS6 Rat Unigene: 12376 Human Unigene: 146275 Mouse Unigene: 53925 Rat

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