Product Name	Hippocalcin
Chinese Name	神经细胞特异性钙Binding protein抗体
Alias	BDR 2; BDR2; Calcium binding protein BDR 2; Calcium binding protein BDR2; Calcium-binding protein BDR-2; Hpca; HPCA_HUMAN; Neuron specific calcium binding protein hippocalcin; Neuron specific calcium-binding protein hippocalcin; Neuron-specific calcium-binding protein hippocalcin; P23K.
Research Area	Cell biology  Neurobiology  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Cow, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Hippocalcin: 101-193/193
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Hippocalcin is a neuron-specific calcium-binding protein found primarily in the plasma membrane of brain and retinal tissue, with increased expression observed in hippocampal pyramidal cells. Through its calcium-dependent signal regulation, hippocalcin can both inhibit rhodopsin kinase and increase phospholipase D2 expression. In order to regulate kinase and phospholipase activity, hippocalcin must bind to the plasma membrane where it can then bind two calcium ions for use in signal regulation. The hippocalcin protein is highly conserved in mouse, rat and human tissue and has a suggested role in neural plasticity and associative memory by contributing to the survival of neurons during aging. The loss of hippocalcin expression is thought to contribute to age-related impairment of post-synaptic functions related to neuronal degradation. Function: May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. Binds two calcium ions. Tissue Specificity: Brain specific. Post-translational modifications: Myristoylation facilitates interaction with membranes. Similarity: Belongs to the recoverin family. Contains 4 EF-hand domains. SWISS: P84074 Gene ID: 3208 Database links: Entrez Gene: 3208 Human Entrez Gene: 509772 Cow Entrez Gene: 15444 Mouse Entrez Gene: 29177 Rat Omim: 142622 Human SwissProt: Q4PL64 Cow SwissProt: P84074 Human SwissProt: P84075 Mouse SwissProt: P84076 Rat Unigene: 632391 Human Unigene: 384452 Mouse Unigene: 11019 Rat
Product Picture	Sample: Cerebral cortex (Mouse) Lysate at 40 ug Primary: Anti- Hippocalcin (SL11348R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 22 kD Sample: Hippocampus (Mouse) Lysate at 40 ug Primary: Anti- Hippocalcin (SL11348R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 22 kD

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