Product Name	SRD5A1
Chinese Name	类固醇5α还原酶1抗体
Alias	3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; Steroid 5-alpha-reductase 1; S5AR 1; 5α-Reductase 1; S5A1_HUMAN.
literatures	Specific References  (8)     |     SL11308R has been referenced in 8 publications. [IF=4.522] Xiao L et al. Dihydrotestosterone synthesis in the sheep corpus luteum and its potential mechanism in luteal regression. J Cell Physiol. 2019 Jan 22.  WB ;  Sheep.   PubMed:30671954 [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone regulation of cyclooxygenase-2 expression in bovine endometrial epithelium cells by androgen receptor mediated EGFR/PI3K/Akt pathway. J Steroid Biochem. 2021 Nov;214:106001  WB,IHC ;  Bovine.   PubMed:10.1016/j.jsbmb.2021.106001 [IF=4.292] Longfei Xiao. et al. Dihydrotestosterone through blockade of TGF-β/Smad signaling mediates the anti-fibrosis effect under hypoxia in canine Sertoli cells. J Steroid Biochem. 2022 Feb;216:106041  WB,IHC ;  Dog.   PubMed:34864206 [IF=3.785] Liu Q et al. Seasonal expressions of androgen receptor, estrogen receptors, 5α-reductases and P450arom in the epididymis of the male muskrat (Ondatra zibethicus). J Steroid Biochem Mol Biol. 2019 Jul 31;194:105433.  WB&IHC-P ;  muskrat.   PubMed:31376460 [IF=2.984] Junjie Hu. et al. Assessment of progesterone synthesis and its regulation role on dihydrotestosterone secretion in sheep epididymis. Gene. 2021 Jul;790:145699  WB ;  Sheep.   PubMed:33964380 [IF=2.923] Hongwei Duan. et al. Melatonin regulates dihydrotestosterone formation via its membrane receptor in the epididymal epithelial cells of sheep. THERIOGENOLOGY. 2022 Dec;:  WB ;  Sheep.   PubMed:36623430 [IF=2.445] Song L et al. DHT and E2 synthesis-related proteins and receptors expression in male yak skin during different hair follicle stages. Gen Comp Endocrinol. 2019 Aug 12:113245.  WB&IHC-P ;  Yak.   PubMed:31415730 [IF=1.574] Hiroto KOBAYASHI. et al. Estrogen synthesis in the stomach of Sprague–Dawley rats: comparison to Wistar rats. 2020 Sep 25  WB ;  Rat.   PubMed:32981898
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	29kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SRD5A1: 101-200/259
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Steroid 5a-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5a-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, which is expressed mainly in the skin; and type 2, which is expressed mainly in the prostate. In cultured human skin cells, 5a-Reductase 1 shows heterogeneity of protein, and has different levels of transcriptional and translational expression. 5a-Reductase 1 is expressed in all portions of the hair follicle, whereas 5a-Reductase 2 is expressed only in mesenchymal portions. In addition, 5a-Reductase 1 is mainly expressed in human breast carcinoma and may play a role in the in situ production and actions of the potent androgen 5a-dihydrotestosterone, including inhibition of cancer cell proliferation in hormone-dependent human breast carcinoma. The 5a-Reductase-3a-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids. Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Subcellular Location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Tissue Specificity: Liver and prostate (at a low level). Similarity: Belongs to the steroid 5-alpha reductase family. SWISS: P18405 Gene ID: 6715 Database links: Entrez Gene: 614612 Cow Entrez Gene: 403716 Dog Entrez Gene: 6715 Human Entrez Gene: 78925 Mouse Entrez Gene: 24950 Rat Omim: 184753 Human SwissProt: A5PJS2 Cow SwissProt: P18405 Human SwissProt: Q68FF9 Mouse SwissProt: P24008 Rat Unigene: 552 Human Unigene: 451912 Mouse Unigene: 483181 Mouse Unigene: 4620 Rat
Product Picture	Sample: Hepg2(Human) Cell Lysate at 30 ug Primary: Anti-SRD5A1 (SL11308R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 29 kD Observed band size: 29 kD

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