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Product Name HOXA3 Chinese Name 同源盒基因HOXA3蛋白抗体 Alias Homeo box 1E; Homeo box A3; Homeobox 1E; Homeobox A3; Homeobox protein HOX A3; Homeobox protein Hox-1E; Homeobox protein Hox-A3; Homeobox protein HOXA3; Homeobox1E; HomeoboxA3; HOX 1; Hox 1.5 like protein; HOX 1E; HOX A3; HOX1; Hox1.5; Hox1.5 like protein; HOX1E; HOXA 3; HOXA3; HXA3_HUMAN; MGC10155. Research Area Cell biology Neurobiology Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Zebrafish, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 46kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HOXA3: 201-300/443 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The Hox proteins play a role in development and cellular differentiation by regulating downstream target genes. Specifically, the Hox proteins direct DNA-protein and protein-protein interactions that assist in determining the morphologic features associated with the anterior-posterior body axis. The mammalian HOX gene complex consists of 39 genes that are located on four linkage groups, which are dispersed over four chromosomes. HOX genes that occupy the same relative position along the 5’ to 3’ coordinate (trans-paralogous genes) are more similar in sequence and expression pattern than adjacent HOX genes on the same chromosome. HoxA3, in conjunction with Pax1, mediates the development of the thymus, parathyroid gland, and carotid body. Its expression in the third pharyngeal arch and pouch is required for development of the third arch artery, and homozygous null HoxA3 mutants lack the carotid body. HoxA3 also regulates hindbrain development by controlling the axon projection pattern of motor neurons and sensory neurons of the proximal and distal ganglia.
Function:
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular Location:
Nucleus.
Similarity:
Belongs to the Antp homeobox family.
Contains 1 homeobox DNA-binding domain.
SWISS:
O43365
Gene ID:
3200
Database links:Entrez Gene: 395231 Chicken
Entrez Gene: 3200 Human
Entrez Gene: 15400 Mouse
Entrez Gene: 58049 Zebrafish
Omim: 142954 Human
SwissProt: Q7T3J5 Chicken
SwissProt: O43365 Human
SwissProt: P02831 Mouse
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