Product Name	FKBP4
Chinese Name	热休克蛋白56抗体
Alias	FKBP4_HUMAN; Peptidyl-prolyl cis-trans isomerase FKBP4; EC:5.2.1.8; FKBP52; PPIase FKBP4; 51 kDa FK506-binding protein (FKBP51); 52 kDa FK506-binding protein (52 kDa FKBP; FKBP-52); 59 kDa immunophilin (p59); FK506-binding protein 4 (FKBP-4); Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed; HBI; p52; Hsp56; FKBP51; FKBP59; PPIase;
Research Area	Signal transduction  Cytoskeleton  Extracellular matrix  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HSP56: 1-100/459
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. The human genome contains several non-transcribed pseudogenes similar to this gene. [provided by RefSeq, Sep 2008] Function: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unliganded steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments (By similarity). The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. Subunit: Homodimer. Associates with HSP90 and HSP70 in unactivated steroid hormone receptor complexes. Also interacts with peroxisomal phytanoyl-CoA alpha-hydroxylase (PHYH). Interacts with HSF1 in the HSP90 complex. Associates with tubulin (By similarity). Interacts with MAPT/TAU (By similarity). Interacts with NR3C1 and dynein (By similarity). Interacts (via TPR domain) with S100A1, S100A2 and S100A6; the interaction is Ca(2+) dependent. Interaction with S100A1 and S100A2 (but not with S100A6) leads to inhibition of FKBP4-HSP90 interaction. Subcellular Location: Cytoplasm; cytosol. Nucleus. Cytoplasm; cytoskeleton. Tissue Specificity: Widely expressed. Post-translational modifications: Phosphorylation by CK2 results in loss of HSP90 binding activity (By similarity). Similarity: Contains 2 PPIase FKBP-type domains. Contains 3 TPR repeats. SWISS: Q02790 Gene ID: 2288 Database links: Entrez Gene: 2288 Human Entrez Gene: 14228 Mouse Entrez Gene: 260321 Rat SwissProt: Q02790 Human SwissProt: P30416 Mouse SwissProt: Q9QVC8 Rat 有研究表明；FKBP52蛋白可能防止Tau蛋白的过度磷酸化，FKBP52可控制致病性Tau蛋白的异常产生。当AD患者的神经细胞FKBP52水平降低时，致病性Tau蛋白将不会沉积，将不能促进脑细胞的变性，FKBP52蛋白是迄今为止发现的唯一一个有抗Tau蛋白特性的蛋白。FKBP52蛋白能降低阿尔茨海默氏症患者大脑中致病性Tau蛋白的产生。

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