Product Name	5HT1B Receptor
Chinese Name	5-羟色胺受体1B抗体
Alias	5HT1B Receptor; 5 HT 1B; 5 HT 1D beta; 5-HT1BR; 5HT1BR; 5 HT1B; 5 HT1B receptor; 5 HT1DB; 5 hydroxytryptamine (serotonin) receptor 1B; 5 hydroxytryptamine receptor 1B; HTR 1B; HTR1B; HTR1D2; HTR1DB; S12; 5 HT1DB; 5 hydroxytryptamine receptor 1B; 5-HT-1B; 5-HT-1D-beta; 5-HT1B; 5-hydroxytryptamine receptor 1B; 5HT1B_HUMAN; HTR1B; HTR1D2; HTR1DB; S12; Serotonin 1D beta receptor; Serotonin receptor 1B; Serotonin 1D beta receptor; Serotonin receptor 1B; HTR1B; HTR1DB; 5-hydroxytryptamine receptor 1B.
literatures	Specific References  (2)     |     SL1125R has been referenced in 2 publications. [IF=3.18] Liu et al. Fluoxetine attenuates chronic methamphetamine-induced pulmonary arterial remodelling: possible involvement of serotonin transporter and serotonin 1B receptor. (2013) Basic.Clin.Pharmacol.Toxicol. 112:77-82  other ;  other.   PubMed:22900600 [IF=2.59] Sun, Tao, et al. "Antihypertensive effect of formononetin through regulating the expressions of eNOS, 5-HT< sub> 2A/1B receptors and ??< sub> 1-adrenoceptors in spontaneously hypertensive rat arteries."European journal of pharmacology (2013)..  Rat.   PubMed:23123056
Research Area	Neurobiology  Channel protein  The cell membrane受体
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Chicken, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	44kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human 5-HTR1B: 121-220/390 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) exerts a wide variety of physiologic functions through a multiplicity of receptors and may be involved in human neuropsychiatric disorders such as anxiety, depression, or migraine. These receptors consist of several main groups subdivided into several distinct subtypes on the basis of their pharmacologic characteristics, coupling to intracellular second messengers, and distribution within the nervous system (Zifa and Fillion, 1992 [PubMed 1359584]). The serotonergic receptors belong to the multigene family of receptors coupled to guanine nucleotide-binding proteins.[supplied by OMIM, Oct 2009]. Function: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Subcellular Location: Cell membrane; Multi-pass membrane protein. Post-translational modifications: Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. Palmitoylated. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P28222 Gene ID: 3351 Database links: Entrez Gene: 3351 Human Omim: 182131 Human SwissProt: P28222 Human Unigene: 123016 Human
Product Picture	Tissue/cell: rat brain tissue(Snr); 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-5-HTR1B Polyclonal Antibody, Unconjugated(SL1125R) 1:300, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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