Product Name	RECQL5
Chinese Name	RecQ解旋酶样蛋白5抗体
Alias	ATP-dependent DNA helicase Q5; DNA helicase, RecQ like type 5; DNA helicase, RECQ-like, type 5; RecQ helicase protein-like 5 beta; RecQ protein-like 5; RecQ protein-like 5, isoform CRA_b; RecQ5; Recq5b; Recql5b; RECQ5_HUMAN.
Research Area	Chromatin and nuclear signals  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	109kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RECQL5: 1-100/991
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	RecQ helicases are implicated in DNA recombination and repair helicases and are critical in genome maintenance. RecQL5 is one of five known RecQ homologues in humans, and defects in three of these (BLM, WRN and RecQ4)are associated with autosomal recessive disorders that involve genomic instability and a predisposition to cancer. The exact role of ReqL5 is unclear. It has been shown in mouse embryonic stem (ES) cells that mutations in the Recql5 genes result in a significant increase in the frequency of sister chromatid exchange (SCE), whereas deleting Recql5 lead to an even higher frequency of SCE. There are three different RecQL5 isoforms - alpha, beta and gamma, produced by alternative splicing. Function: May have an important role in DNA metabolism. Subunit: Interacts with TOP3A and TOP3B. Subcellular Location: Cytoplasmic and Nuclear, depending on the isoform. Tissue Specificity: Ubiquitous Similarity: Belongs to the helicase family. RecQ subfamily. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. SWISS: O94762 Gene ID: 9400 Database links: Entrez Gene: 483317 Dog Entrez Gene: 9400 Human Entrez Gene: 287834 Rat Omim: 603781 Human SwissProt: O94762 Human Unigene: 632229 Human Unigene: 198916 Rat

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