Product Name	PTBP1
Chinese Name	核糖核酸Binding protein1抗体
Alias	Heterogeneous nuclear ribonucleoprotein I; Heterogeneous Nuclear Ribonucleoprotein Polypeptide I; hnRNP I; HNRNPI; HNRPI; MGC10830; MGC8461; Polypyrimidine Tract Binding Protein 1; Polypyrimidine tract binding protein; Polypyrimidine tract-binding protein 1; pPTB; PTB 1; PTB 2; PTB 3; PTB 4; PTB; PTB T; PTB1; PTB2; PTB3; PTB4; PTBP 1; PTBP1; PTBP1_HUMAN; PTBT; RNA Binding Protein; 57 kDa RNA binding protein PPTB 1; 57 kDa RNA binding protein PPTB1; 57 kDa RNA-binding protein PPTB-1.
Research Area	Chromatin and nuclear signals  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	57kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PTBP1: 451-531/531
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Function: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Subunit: Contains 4 RRM (RNA recognition motif) domains. Subcellular Location: Nucleus. Similarity: Contains 4 RRM (RNA recognition motif) domains. SWISS: P26599 Gene ID: 5725 Database links: Entrez Gene: 5725 Human Entrez Gene: 19205 Mouse Entrez Gene: 29497 Rat Omim: 600693 Human SwissProt: P26599 Human SwissProt: P17225 Mouse SwissProt: Q00438 Rat Unigene: 172550 Human Unigene: 265610 Mouse Unigene: 472059 Mouse Unigene: 64440 Rat
Product Picture	Sample: A549(Human) Cell Lysate at 30 ug Primary: Anti-PTBP1 (SL11220R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kD Observed band size: 57 kD Sample: Jurkat(Human) Cell Lysate at 30 ug Primary: Anti-PTBP1 (SL11220R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kD Observed band size: 57 kD Paraformaldehyde-fixed, paraffin embedded (Human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTBP1) Polyclonal Antibody, Unconjugated (SL11220R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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