TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Pumilio 1 Chinese Name PUM1蛋白抗体 Alias HSPUM; KIAA0099; PUM 1; PUM L1; PUM1; PUM1_HUMAN; PUMH 1; PUMH; PUMH1; Pumilio homolog 1; Pumilio-1; Pumilio1; PUML 1; PUML1. Research Area Developmental biology Stem cells Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 126kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Pumilio 1: 201-300/1186 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Pumilio 1, also known as PUM1, PUMH1 (Pumilio homolog 1), HSPUM, PUMH or PUML1, is a homolog of the Drosophila Pumilio protein and belongs to the PUF family. The PUF family is comprised of evolutionarily conserved proteins that contain a C-terminal RNA binding domain made up of eight highly conserved tandem repeats. PUF proteins function as sequence-specific RNA-binding proteins and bind NREs (nanos response elements) in the 3’-untranslated regions of target mRNAs. They play an important role mediating mRNA stabilization and repressing translation. Pumilio 1 is a typical PUF protein expressed in fetal tissues as well as adult stomach, kidney, intestine, muscle, brain and heart tissues. Pumilio 1 localizes to the cytoplasm and is believed to participate in cell fate, cell development, cell differentiation and maintenance of somatic stem cells.
Function:
Sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. May be required to support proliferation and self-renewal of stem cells (By similarity).
Subunit:
Binds in a sequence-specific manner to the 3'-UTR of some mRNAs.
Subcellular Location:
Cytoplasm (Probable).
Tissue Specificity:
Expressed in brain, heart, kidney, muscle, intestine and stomach. Not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata and putamen. Expressed in all fetal tissues tested.
Similarity:
Contains 1 PUM-HD domain.
Contains 8 pumilio repeats.
SWISS:
Q14671
Gene ID:
9698
Database links:Entrez Gene: 9698 Human
Entrez Gene: 80912 Mouse
Omim: 607204 Human
SwissProt: Q14671 Human
SwissProt: Q80U78 Mouse
Unigene: 281707 Human
Unigene: 440206 Mouse
Product Picture
Scan Wechat Qrcode