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Rabbit Anti-KLC1 antibody
Rabbit Anti-KLC1 antibody
Kinesin 2 60/70kDa; Kinesin light chain 1; Kinesin2; Kinesin-2; KLC 1; KLC; KLC1; KLC1_HUMAN; KNS 2; KNS 2A; KNS2; KNS2A; Medulloblastoma antigen MU MB 2.50; MGC15245.
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  • NO.:SL11212R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,(predicted: Human,Rat,Chicken,Cow,Horse,Rabbit,Sheep,)
    Applications:WB ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name KLC1
Chinese Name 驱动蛋白2抗体
Alias Kinesin 2 60/70kDa; Kinesin light chain 1; Kinesin2; Kinesin-2; KLC 1; KLC; KLC1; KLC1_HUMAN; KNS 2; KNS 2A; KNS2; KNS2A; Medulloblastoma antigen MU MB 2.50; MGC15245.  
Research Area Neurobiology  Signal transduction  Cytoskeleton  Extracellular matrix  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, Rat, Chicken, Cow, Horse, Rabbit, Sheep, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 65kDa
Cellular localization cytoplasmic 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human KLC1: 1-100/573 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail The kinesin family of motor proteins comprise at least two forms of conventional kinesin (kinesin-I). They are encoded by different genes and designated ubiquitous kinesin, which is expressed in all cells and tissues, and neuronal kinesin, which is expressed exclusively in neuronal cells. Conventional kinesin is a heterotetramer of two kinesin heavy chain subunits and two kinesin light chain subunits. While the kinesin heavy chain contains motor activity, evidence suggests that the kinesin light chain is involved in either modulation of kinesin heavy chain activity or in cargo binding. The motor protein kinesin is a heterotetramer composed of two heavy chains and two light chains. Kinesin motor activity is dependent on the presence of ATP and microtubules.

Function:
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Subunit:
Belongs to the kinesin light chain family. Contains 6 TPR repeats.

Subcellular Location:
Cytoplasm; cytoskeleton.

Tissue Specificity:
Found in a variety of tissues. Mostly abundant in brain and spine.

Post-translational modifications:
Isoform I is phosphorylated on Ser-600. Isoform J is phosphorylated on Ser-631.

Similarity:
Belongs to the kinesin light chain family.
Contains 6 TPR repeats.

SWISS:
Q07866

Gene ID:
3831

Database links:

Entrez Gene: 3831 Human

Entrez Gene: 16593 Mouse

Entrez Gene: 171041 Rat

Omim: 600025 Human

SwissProt: Q07866 Human

SwissProt: O88447 Mouse

SwissProt: P37285 Rat

Unigene: 20107 Human

Unigene: 657678 Human

Unigene: 278357 Mouse

Unigene: 106230 Rat



Product Picture
Sample:
Spinal cord (Mouse) Lysate at 40 ug
Primary: Anti- KLC1 (SL11212R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 65 kD
Observed band size: 65 kD

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