Product Name	SOX12
Chinese Name	核转录因子SOX22抗体
Alias	SOX22; Homo sapiens SRY (sex determining region Y) box 12; Protein SOX-22; SOX 12; SOX 12 protein; SOX 22; SOX 22 protein; SOX12 protein; SOX12_HUMAN; SOX22 protein; SRY (sex determining region Y) box 12; SRY (sex determining region Y) box 22; SRY box 12; SRY box 22; SRY related HMG box gene 22; Transcription factor Sox-12.
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SOX22: 51-150/315
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Function: Binds to the sequence 5'-AACAAT-3' (By similarity). Subcellular Location: Nucleus. Tissue Specificity: Expressed most abundantly in the CNS. Also expressed in fetal brain and kidney and adult heart, pancreas, testis and ovary. Other tissues were only weakly positive. Similarity: Contains 1 HMG box DNA-binding domain. SWISS: O15370 Gene ID: 6666 Database links: Entrez Gene: 6666 Human Entrez Gene: 20667 Mouse SwissProt: O15370 Human SwissProt: Q04890 Mouse

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