Product Name	NR2E1
Chinese Name	核受体蛋白NR2E1抗体
Alias	NR2E1 / Tailless; Tailless; hTll; nr2e1; NR2E1_HUMAN; Nuclear receptor subfamily 2 group E member 1; Nuclear receptor TLX; Orphan nuclear receptor NR2E1; Protein tailless homolog; Tailless homolog; Tll; TLX; XTLL.
Research Area	Neurobiology  Signal transduction  Stem cells  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NR2E1/Tailless: 321-385/385
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus. Mutations in the gene that encodes NR2E1 may lead to retinal dystrophy, a disorder characterized by a reduction in the thickness of the retina. Function: Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required for brain development. May be involved in the regulation of retinal development. Subunit: Monomer (By similarity). Interacts with ATN1; the interaction represses the transcription Subcellular Location: Nucleus. Tissue Specificity: Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus. Similarity: Belongs to the nuclear hormone receptor family. NR2 subfamily. Contains 1 nuclear receptor DNA-binding domain. SWISS: Q9Y466 Gene ID: 7101 Database links: Entrez Gene: 7101 Human Entrez Gene: 396082 Chicken Entrez Gene: 21907 Mouse Entrez Gene: 684085 Rat Omim: 603849 Human SwissProt: Q91379 Chicken SwissProt: Q9Y466 Human SwissProt: Q3UXE8 Mouse SwissProt: Q64104 Mouse SwissProt: Q78ZM1 Mouse SwissProt: P70052 Xenopus laevis SwissProt: Q6DEH0 Zebrafish Unigene: 157688 Human Unigene: 287100 Mouse Unigene: 1067 Xenopus laevis

Cartpieces

• 
• 1

  1Delete

• 
• 5

  5Delete

• 
• S

  SDelete

• 
• R

  RDelete

• 
• +

  +Delete

• 
• 2

  2Delete

• Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• N

  NDelete

• 
• N

  NDelete

• 

• Delete

• 
• i

  iDelete

• 
• i

  iDelete

• Delete

• 
• 1

  1Delete

• Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• Delete

• 
• 2

  2Delete

• 
• 1

  1Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 1

  1Delete

• 
• 1

  1Delete

• Delete

• 
• -

  -Delete

• 
• -

  -Delete

• 
• 0

  0Delete

• Delete

• 
• t

  tDelete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• 0

  0Delete

• 
• f

  fDelete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• Delete

• 
• 4

  4Delete

• 
• $

  $Delete

• Delete

• 
• 0

  0Delete

• Delete

• Delete

• Delete

• 
• R

  RDelete

• 
• 5

  5Delete

• 
• A

  ADelete

Totalgoods,subtotals:￥Checkout