Product Name	Pregnancy zone protein
Chinese Name	妊娠区带蛋白PZP抗体
Alias	A1m antibody; C3 and PZP like alpha-2 macroglobulin domain containing protein 6; Complement component 3 and pregnancy zone protein like alpha 2 macroglobulin domain containing protein 6; CPAMD6; PZP; PZP_HUMAN.
Research Area	Neurobiology  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	161kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Pregnancy zone protein: 951-1050/1482
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Pregnancy Zone protein is a 1,482 amino acid secreted protein that belongs to the protease inhibitor I39 family and exists as multiple alternatively spliced isoforms. Expressed predominately in plasma and in late-pregnancy sera, Pregnancy Zone protein functions as a disulfide-linked homotetramer that is able to trap and inhibit proteinases, thus playing a role in the regulation of protein splitting and small peptide formation. The gene encoding Pregnancy Zone protein maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders. Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Subunit: Homotetramer, which consists of two pairs of disulfide-linked chains. Subcellular Location: Secreted. Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. SWISS: P20742 Gene ID: 5858 Database links: Entrez Gene: 5858 Human Omim: 176420 Human SwissProt: P20742 Human
Product Picture	Sample: Plasma (Mouse) Lysate at 40 ug Serum (Mouse) Lysate at 40 ug Primary: Anti-Pregnancy zone protein (SL11176R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 161 kD Observed band size: 161 kD

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