Product Name	KY
Chinese Name	脊柱侧后凸畸形肽酶抗体
Alias	KY; KY_HUMAN; Kyphoscoliosis peptidase.
Research Area	Developmental biology  Neurobiology  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	75kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Kyphoscoliosis peptidase: 51-150/661
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	KY peptidase (Kyphoscoliosis peptidase) is a 561 amino acid cytoskeleton protease that interacts with several sarcomeric cytoskeletal proteins, including Filamin 2. KY peptidase probably plays a role in the maturation, function and stabilization of the neuromuscular junction. KY-null mouse mutants exhibit distinct irregular subceullular Filamin 2 localization, suggesting that KY peptidase deficiency may be the cause of several types of limb-girdle muscular dystrophies. Function: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC. Subunit: Interacts with IGFN1 and FLNC. Subcellular Location: Cytoplasm Tissue Specificity: Specifically expressed in skeletal and cardiac muscle. Similarity: Belongs to the transglutaminase-like superfamily. SWISS: Q8NBH2 Gene ID: 339855 Database links: Entrez Gene: 339855 Human Entrez Gene: 16716 Mouse Omim: 605739 Human SwissProt: Q8NBH2 Human SwissProt: Q8C8H8 Mouse Unigene: 146730 Human

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