Product Name	Cadherin 10
Chinese Name	钙粘附分子10抗体
Alias	cadherin10; cadherin-10; Cadherin 10 (T2 cadherin); Cadherin 10 type 2 (T2 cadherin); Cadherin 10 type 2; Cadherin10; T2 cadherin; CAD10_HUMAN.
Research Area	Neurobiology  Signal transduction  Cell adhesion molecule  Cytoskeleton  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	82kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Cadherin 10: 31-130/788 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. T2-cadherin, also known as cadherin-10 or CDH10, is a 788 amino acid single-pass type I membrane protein that belongs to the cadherin family and contains five cadherin domains. Expressed predominately in brain, but also found in prostate and both adult and fetal kidney, T2-cadherin functions as a calcium-dependent cell adhesion protein that is thought to be involved in the maintenance of synaptic adhesions, axon outgrowth and guidance. Function: Cadherin 10 is a type II classical cadherin from the cadherin superfamily. These are integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Subcellular Location: Cell membrane; Single-pass type I membrane protein Tissue Specificity: Predominantly expressed in brain. Also found in adult and fetal kidney. Very low levels detected in prostate and fetal lung. SWISS: Q9Y6N8 Gene ID: 1008 Database links: Entrez Gene: 1008 Human Entrez Gene: 320873 Mouse Entrez Gene: 29181 Rat Omim: 604555 Human SwissProt: Q9Y6N8 Human SwissProt: P70408 Mouse Unigene: 92489 Human Unigene: 117794 Mouse Unigene: 446240 Mouse Unigene: 83592 Rat

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