Product Name	SPRR1a
Chinese Name	角质蛋白α抗体
Alias	19 kDa pancornulin; Cornifin A; Cornifin alpha; CornifinA; Small proline rich protein 1A; Small proline rich protein IA; spr; SPR IA; SPRK; SPRR 1a; SPRR1A protein; SPR1A_HUMAN.
literatures	Specific References  (2)     |     SL11162R has been referenced in 2 publications. [IF=2.311] Yu Deng. et al. High SPRR1A expression is associated with poor survival in patients with colon cancer. Oncol Lett. 2020 May;19(5):3417-3424  IHC ;  Human.   PubMed:32269614 [IF=1.871] Deng Y et al. High SPRR1A expression is associated with poor survival in patients with colon cancer. Oncol Lett. 2020 May;19(5):3417-3424.  IHC ;  huamn.   PubMed:32269614
Research Area	immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	10kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SPRR1a/Cornifin A: 21-89/89
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The small proline rich protein (SPRR) gene family encodes a conserved group of cornified envelope (CE) proteins that are part of the human epidermal differentiation complex (EDC). The formation of the cornified envelope during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Additionally, the expression of SPRR proteins is linked to keratinocyte terminal differentiation. The SPRR gene family, namely comprises three subclasses of genes, SPRR1 (which contains two members), SPRR2 (which contains eight members) and SPRR3 (which contains one member). SPRR1 is found predominantly in follicular epidermis and oral mucosa, SPRR2 is expressed coherently in follicular and interfollicular epidermis and SPRR3 is absent in epidermis and strongly expressed in internal squamous. Function: The ability of neurons to regenerate an axon after injury is determined by both the surrounding environment and factors intrinsic to the damaged neuron. Neuronal SPRR1A is likely a significant contributor to successful nerve regeneration. The small proline-rich repeat protein 1A (SPRR1A) is not detectable in uninjured neurons but is induced by >60-fold after peripheral axonal damage being localized to injured neurons and axons. SPRR1A is one of a group of epithelial differentiation genes, including s100c and p21/waf, that are cocurrently induced in neurons by axotomy. Overexpressed SPRR1A colocalizes with F-actin in membrane ruffles and augments axonal outgrowth on a range of substrates. In axotomized sensory neurons, reduction of SPRR1A function restricts axonal outgrowth. Subcellular Location: Cytoplasmic Similarity: Belongs to the cornifin (SPRR) family. SWISS: P35321 Gene ID: 6698 Database links: Entrez Gene: 6698 Human Omim: 182265 Human SwissProt: P35321 Human Unigene: 46320 Human

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