Product Name	beta Adducin
Chinese Name	内收蛋白抗体
Alias	ADD 2; ADD B; ADD2; ADDB; ADDL; Adducin 2 (beta); Adducin 2; Adducin like; Adducin like protein 70; Adducin2; Beta adducin; Erythrocyte adducin alpha subunit; Erythrocyte adducin subunit alpha; Erythrocyte adducin subunit beta; MGC3339; MGC44427; ADDB_HUMAN.
Research Area	Cell biology  Signal transduction  Binding protein  Cell type markers  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	WB=1:200-1000 ELISA=1:500-5000 IHC-P=1:100-500 IHC-F=1:200-1000 IF=1:200-1000 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	80kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human beta Adducin protein: 401-500/725
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Adducins are a family of cytoskeletal proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha and beta adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha and gamma adducins are ubiquitously expressed. In contrast, beta adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca2+/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. Function: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin. Calmodulin binds preferentially to the beta subunit. Subunit: Heterodimer of an alpha and a beta subunit. Subcellular Location: Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Tissue Specificity: Expressed mainly in brain, spleen, kidney cortex and medulla, and heart. Also expressed in human umbilical vein endothelial cells, human vascular smooth muscle cells, kidney tubular cells and K-562 cell line. Post-translational modifications: The N-terminus is blocked. Similarity: Belongs to the aldolase class II family. Adducinbn subfamily. SWISS: P35612 Gene ID: 119 Database links: Entrez Gene: 119 Human Entrez Gene: 11519 Mouse Entrez Gene: 24171 Rat Omim: 102681 Human SwissProt: P35612 Human SwissProt: Q9QYB8 Mouse SwissProt: Q05764 Rat Unigene: 188528 Human Unigene: 11353 Rat 内收蛋白(Adducin）是一种膜骨架蛋白，内收蛋白可与肌动蛋白及血影蛋白复合体结合，并且通过Ca2+和钙调蛋白的作用影响骨架蛋白的稳定性，从而影响红细胞的形态.

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