Product Name	PCDHA5
Chinese Name	原钙粘附蛋白α5抗体
Alias	Cadherin related neuronal receptor 6; CNR 6; CNR6; CNRN 6; CNRN6; CNRS 6; CNRS6; CRNR 6; CRNR6; Ortholog of mouse CNR6; PCDH alpha5; PCDHA 5; Protocadherin alpha 5; PCDA5_HUMAN.
Research Area	Neurobiology  Signal transduction  Cell adhesion molecule  Cytoskeleton  Extracellular matrix  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	99kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PCDHA5: 351-250/936 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. PCDHA5 (Protocadherin alpha-5) is one of fifteen members of the protocadherin alpha protein family that is expressed in neurons. PCDHA5 is a 936 amino acid single-pass type I membrane protein containing 6 cadherin domains. Localized to the cell membrane, PCDHA5 functions as a calcium-dependent cell-adhesion protein that is present in synaptic junctions and is essential to the establishment and maintenance of certain cell-cell interactions. PCDHA5 is expressed as 3 isoforms produced by alternative splicing. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single pass type I membrane protein. Similarity: Contains 6 cadherin domains. SWISS: Q9Y5H7 Gene ID: 56143 Database links: Entrez Gene: 56143 Human Omim: 606311 Human SwissProt: Q9Y5H7 Human

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