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Product Name PCDHA3 Chinese Name 原钙粘附蛋白α3抗体 Alias KIAA0345 like 11; PCDH alpha 3; Protocadherin alpha 3; PCDA3_HUMAN. Research Area Neurobiology Signal transduction Cell adhesion molecule Cytoskeleton Extracellular matrix The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 99kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PCDHA3: 131-230/950 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protein products of PCDH-alpha genes interact with Integrin ∫1 to promote cell adhesion and form oligomers with PCDH-gamma proteins at specific membrane sites. PCDHA3 (Protocadherin alpha-3) is a 950 amino acid single-pass transmembrane protein that contains six cadherin domains. PCDHA3 is a unique cadherin in that it likely functions in spermatogenesis and may also have a role in organizing germ cell-specific structures, such as the flagellum, acrosome and intercellular bridge. There are two isoforms of PCDHA13 that are produced as a result of alternative splicing events.
Function:
PCDHA3 contains six cadherin domains. It is thought to be a calcium dependent cell adhesion protein and may be involved in the establishment and maintenance of specific neuronal connections in the brain. There are two named isoforms.
Subcellular Location:
Cell membrane; Single pass type I membrane protein.
Similarity:
Contains 6 cadherin domains.
SWISS:
Q9Y5H8
Gene ID:
56145
Database links:Entrez Gene: 56145 Human
Entrez Gene: 192163 Mouse
Omim: 606309 Human
SwissProt: Q9Y5H8 Human
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