Product Name	PCDH1
Chinese Name	原钙粘附蛋白1抗体
Alias	Cadherin like 1; Cadherin like protein 1; PC 42; PC42; PCDH 1; PCDH-1; PCDH 42; PCDH42; Protocadherin 1; Protocadherin 42; Protocadherin1; Protocadherin42.
Research Area	Signal transduction  Cell adhesion molecule  Cytoskeleton  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	110kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PCDH1: 51-150/1060 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Protocadherins are a subfamily of cadherins, a large group of related glycoproteins that mediate calcium-dependent cell-to-cell adhesion via a homophilic mechanism. Involved in a variety of functions, protocadherins help to regulate neural development and synapse formation. PCDH1 is a 1,026 amino acid single-pass type I membrane protein that contains seven cadherin domains and is a member of the protocadherin family. Localized to cell-cell and cell-matrix boundaries and expressed at high levels in brain and neuro-glial cells, PCDH1 is thought to be involved in cell adhesion and cell-cell interactions and may play a role in neuronal development. PCDH1 contains a C-terminal cytoplasmic region, an extracellular region and a transmembrane region, and is expressed as two isoforms due to alternative splicing events. Function: PCDH1 (Protocadherin 1) belongs to the protocadherin family, a subfamily of the cadherin superfamily. It is a membrane protein found at cell-cell boundaries suggesting a role in cell-cell interaction processes. It is involved in neural cell adhesion, suggesting a possible role in neuronal development. Subcellular Location: Cell junction. Cell membrane. Single-pass type I membrane protein. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. Tissue Specificity: Highly expressed in the brain and neuro-glial cells. Similarity: Contains 7 cadherin domains. SWISS: Q08174 Gene ID: 5097 Database links: Entrez Gene: 5097 Human Omim: 603626 Human SwissProt: Q08174 Human Unigene: 79769 Human

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