Product Name	Ninjurin 2
Chinese Name	神经损伤诱导蛋白2/NINJ2抗体
Alias	Nerve injury induced protein 2; Ninjurin2; Ninjurin-2; NINJ2; NINJ2_HUMAN.
Research Area	Neurobiology  Cell adhesion molecule  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	16kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Ninjurin 2: 1-100/142 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Ninjurin family proteins are multi-pass membrane proteins induced by nerve injury in Schwann cells and dorsal root ganglion neurons. Nunjurin proteins act as homophilic cell adhesion molecules that promote axonal growth. Ninjurin proteins also play a role in the formation and function of other tissues. Ninjurin-1 is widely expressed in adult and embryonic tissues, particularly those with epithelial origin. Ninjurin-2 is also widely expressed, with highest levels in adult bone marrow and peripheral blood lymphocytes and embryo liver, thymus and heart. The genes that encode the Ninjurin proteins map to a region known to cause several genetic disorders, including hereditary sensory neuropathy type I and type II (HSN1 and HSN2). However, no link between mutations in the genes encoding Ninjurins and the diseases have been found. Function: Ninjurin2 is an homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Subunit: Homophilic cell adhesion molecule that promotes axonal growth. May play a role in nerve regeneration and in the formation and function of other tissues. Subcellular Location: Membrane; Multi-pass membrane protein Tissue Specificity: Widely expressed. In adult, higher expression in the bone marrow and peripheral blood lymphocytes, medium in the lung, lymph node, thyroid, uterus, thymus, spleen, prostate and skeletal muscle, lower in the liver, placenta, brain, heart and kidney. In embryo, higher expression in the thymus, heart and liver, lower in the spleen, lung, brain and kidney. Similarity: Belongs to the ninjurin family. SWISS: Q9NZG7 Gene ID: 4815 Database links: Entrez Gene: 4815 Human GenBank: BC057766 Human Omim: 607297 Human SwissProt: Q9NZG7 Human Unigene: 656450 Human

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