Product Name	LRFN3
Chinese Name	神经突触粘附样分子4抗体
Alias	SALM4; Fibronectin type II immunoglobulin and leucine rich repeat domains 1; Fibronectin type II, immunoglobulin and leucine rich repeat domains 1; FIGLER1; Leucine rich repeat and fibronectin type III domain containing 3; Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Lrfn3; LRFN3_HUMAN; Synaptic adhesion-like molecule 4.
Research Area	Neurobiology  Cell adhesion molecule  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	65kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRFN3/SALM4: 61-150/628 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LRFN3 is a 628 amino acid single-pass type I membrane protein that belongs to the LRFN family. Containing seven LRR (leucine-rich) repeats, LRFN3 also contains one fibronectin type-III domain, one Ig-like (immunoglobulin-like) domain, one LRRCT domain and one LRRNT domain. As a cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca2+-independent manner, LRFN3 promotes neurite outgrowth in hippocampal neurons. LRFN3 forms homomeric complexes across cell junctions (between adjacent cells), and can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. The gene that encodes LRFN3 consists of more than 8,000 bases and maps to human chromosome 19q13.12. Function: Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. Subunit: Can form heteromeric complexes with LRFN1, LRFN2, LRFN4 and LRFN5. Able to form homomeric complexes across cell junctions, between adjacent cells. Does not interact with DLG4 (By similarity). Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane (By similarity). Cell junction, synapse, postsynaptic cell membrane (By similarity). Post-translational modifications: N-glycosylated. Similarity: Belongs to the LRFN family. Contains 1 fibronectin type-III domain. Contains 1 Ig-like (immunoglobulin-like) domain. Contains 7 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: Q9BTN0 Gene ID: 79414 Database links: Entrez Gene: 79414 Human Entrez Gene: 233067 Mouse Entrez Gene: 308495 Rat Omim: 612809 Human SwissProt: Q9BTN0 Human SwissProt: Q8BLY3 Mouse SwissProt: B0BNK7 Rat Unigene: 143792 Human Unigene: 23157 Mouse Unigene: 50030 Rat

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