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Product Name FAT3 Chinese Name 钙粘蛋白15抗体 Alias Cadherin family member 15; CDHF15; CDHR10; FAT tumor suppressor homolog 3; Fat3; FAT3_HUMAN; hFat3; Protocadherin Fat 3. Research Area Neurobiology Cell adhesion molecule Cytoskeleton Transmembrane protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 512kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CDHF15/FAT3: 601-800/4589 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell to cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short C-terminal intracellular domain interacts with a variety of cytoplasmic proteins, including ∫-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT3 (FAT tumor suppressor homolog 3, also known as CDHF15 or CDHR10, is a 4,589 amino acid single-pass type I membrane protein expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate. Containing thirty-three cadherin domains, four EGF-like domains and one laminin G-like domain, FAT3 may participate in the interactions between neurites derived from specific subsets of neurons during development.
Function:
May play a role in the interactions between neurites derived from specific subsets of neurons during development.
Subcellular Location:
Membrane; Single-pass type I membrane protein (Potential).
Tissue Specificity:
Expressed in ES cells, primitive neuroectoderm, fetal brain, infant brain, adult neural tissues and prostate.
Similarity:
Contains 33 cadherin domains.
Contains 4 EGF-like domains.
Contains 1 laminin G-like domain.
SWISS:
Q8TDW7
Gene ID:
120114
Database links:Entrez Gene: 120114 Human
Omim: 612483 Human
SwissProt: Q8TDW7 Human
Unigene: 98523 Human
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