Product Name	ASTN2
Chinese Name	星形肌动蛋白抗体
Alias	Astn2; Astn-2; Astn 2; ASTN2_HUMAN; Astrotactin 2; Astrotactin2; Astrotactin-2; bA67K19.1; KIAA0634.
Research Area	immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	143kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ASTN2: 21-120/1339 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Neuronal migration of the central nervous system is a specialized form of cell motility that takes place in the laminar structure of the cortical regions of brain. Astrotactin is a neuronal cell surface protein expressed on postmitotic neuronal precursors in the cerebellum, hippocampus, cerebrum, and olfactory bulb. Astrotactin 2 is a paralog of Astrotactin. Astrotactin mediates neuron-astroglial interactions and is also implicated in synaptic development as well as many other neuronal activities. Astrotactin has three epidermal growth factor repeat domains and two fibronectin type III repeat domains. The human Astrotactin gene shows extensive homology to the mouse Astrotactin gene. Mutations in the Astrotactin gene are linked to neuronal migration defects in both species. Subcellular Location: Membrane. Similarity: Belongs to the astrotactin family. Contains 3 EGF-like domains. Contains 1 fibronectin type-III domain. SWISS: O75129 Gene ID: 23245 Database links: Entrez Gene: 23245 Human Entrez Gene: 56079 Mouse Entrez Gene: 100361323 Rat Omim: 612856 Human SwissProt: O75129 Human SwissProt: Q80Z10 Mouse Unigene: 601562 Human Unigene: 445312 Mouse Unigene: 162821 Rat

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