Product Name	AMIGO1
Chinese Name	粘附分子IgG样结构域蛋白1抗体
Alias	Adhesion molecule with Ig like domain 1; ali2; Alivin 2; AMIGO 1; AMIGO; AMIGO protein; Amphoterin induced gene and ORF (Amigo); Amphoterin induced gene and ORF; Amphoterin induced protein 1; KIAA1163; AMGO1_HUMAN.
Research Area	Neurobiology  Signal transduction  Cell adhesion molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	52kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human AMIGO1: 131-230/493 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The amphoterin-induced gene and ORF (AMIGO) family of proteins consists of AMIGO-1, AMIGO-2 and AMIGO-3. All three members are single pass type I membrane proteins that contain several leucine-rich repeats, one IgG domain, and a transmembrane domain. The AMIGO proteins are specifically expressed on fiber tracts of neuronal tissues and participate in their formation. The AMIGO proteins can form complexes with each other, but can also bind itself. AMIGO-1, also designated Alivin-2, promotes growth and fasciculation of neurites and plays a role in myelination and fasciculation of developing neural axons. In cerebellar neurons, AMIGO-2 (Alivin-1) is crucial for depolarization-dependent survival. Similar to AMIGO-1 and AMIGO-2, AMIGO-3 (Alivin-3) plays a role in homophilic and/or heterophilic cell-cell interaction and signal transduction. Function: AMIGO1 promotes growth and fasciculation of neurites from cultured hippocampal neurons. It may be involved in fasciculation as well as myelination of developing neural axons and have a role in regeneration as well as neural plasticity in the adult nervous system. AMIGO1 may also mediate homophilic as well as heterophilic cell-cell interaction and contribute to signal transduction through its intracellular domain. Subunit: Homodimer, and heterodimer with AMIGO2 and AMIGO3. Subcellular Location: Membrane; Single-pass type I membrane protein. Cell projection; axon. Note: Associated with axons of neuronal cells. Similarity: Belongs to the immunoglobulin superfamily. AMIGO family. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: Q86WK6 Gene ID: 57463 Database links: Entrez Gene: 57463 Human Entrez Gene: 229715 Mouse Entrez Gene: 295365 Rat SwissProt: Q86WK6 Human SwissProt: Q80ZD8 Mouse SwissProt: Q80ZD7 Rat Unigene: 726479 Human Unigene: 275752 Mouse Unigene: 116338 Rat
Product Picture	Sample: Hippocampus (Mouse) Lysate at 40 ug Cerebral cortex (Mouse) Lysate at 40 ug Cerebellum (Mouse) Lysate at 40 ug Primary: Anti-AMIGO1 (SL11070R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kD Observed band size: 52 kD

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