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Rabbit Anti-SNTG2 antibody
Rabbit Anti-SNTG2 antibody
G2SYN; Gamma2-syntrophin; SNTG2; SYN5; Syntrophin-5; Syntrophin5; Syntrophin 5; Syntrophin gamma 2; SNTG2_HUMAN.
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  • NO.:SL11065R
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:(predicted: Human,Mouse,Rat,)
    Applications:WB ELISA IHC-P IHC-F ICC IF
    concentration:1mg/ml
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Details

Product Name SNTG2
Chinese Name 肌蛋白Binding proteinγ2抗体
Alias G2SYN; Gamma2-syntrophin; SNTG2; SYN5; Syntrophin-5; Syntrophin5; Syntrophin 5; Syntrophin gamma 2; SNTG2_HUMAN.  
Research Area Neurobiology  Channel protein  Cell adhesion molecule  Extracellular matrix  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, Mouse, Rat, )
Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight 60kDa
Cellular localization cytoplasmic The cell membrane 
Form Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human SNTG2: 181-280/539 
Lsotype IgG
Purification affinity purified by Protein A
Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed PubMed
Product Detail Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy.

Function:
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).

Subunit:
Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.

Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane.

Tissue Specificity:
Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia.

Similarity:
Belongs to the syntrophin family.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.

SWISS:
Q9NY99

Gene ID:
54221

Database links:

Entrez Gene: 54221 Human

Omim: 608715 Human

SwissProt: Q9NY99 Human

Unigene: 449545 Human

Unigene: 526395 Human



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