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Product Name TBX2 Chinese Name 新型抑癌基因抗体 Alias T-bet; T-box2; T-box Protein 2; T-box transcription factor TBX2; T-box protein 2; FLJ10169; HGNC: 11597; T box 2; T box transcription factor TBX2; TBX2; TBX2_HUMAN. Research Area Tumour Cell biology Signal transduction Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species Human, Rat, (predicted: Mouse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 74kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human TBX2: 401-500/701 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene.
Function:
Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence.
Subunit:
Interacts with PML (isoform-PML-2, isoform PML-3 and isoform PML-4).
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed primarily in adult in kidney, lung, and placenta. Weak expression in heart and ovary.
Similarity:
Contains 1 T-box DNA-binding domain.
SWISS:
Q13207
Gene ID:
6909
Database links:
Entrez Gene: 6909 Human
Entrez Gene: 21385 Mouse
Omim: 600747 Human
SwissProt: Q13207 Human
SwissProt: Q60707 Mouse
Unigene: 531085 Human
Unigene: 287052 Mouse
经研究发现,在人黑色素瘤及很多恶性Tumour组织中普遍存在TBX2基因表达的增高,该蛋白与恶性Tumour的发生、发展密切相关.TBX2基因被认为是一种新发现的抑癌基因。Product Picture Tissue/cell: rat lung tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;
Incubation: Anti-TBX2/T-box2 Polyclonal Antibody, Unconjugated(SL1104R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining
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