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Product Name Bestrophin 3 Chinese Name 卵黄状黄斑病蛋白3抗体 Alias Vitelliform macular dystrophy 2 like protein 3; BEST 3; BEST3; BEST3_HUMAN; Bestrophin-3; Bestrophin3; Vitelliform macular dystrophy 2 like 3; Vitelliform macular dystrophy 2-like protein 3; VMD2L3. Research Area Tumour Signal transduction Channel protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 76kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Bestrophin 3: 45-92/668 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Bestrophin-3 is a 668 amino acid member of the Bestrophin family of proteins. Members of the Bestrophin family are transmembrane proteins that contain a high percentage of aromatic residues, a conserved RFP (arg-phe-pro) motif and they function as anion channels. Expressed predominantly in skeletal muscle but also found in spinal cord, brain, testis, thymus, retina and bone marrow, Bestrophin-3 forms calcium-sensitive chloride channels. In addition, Bestrophin-3 contains an AI (auto-inhibitory) domain that is capable of regulating the anion channel activity. Due to alternative splicing events, three isoforms exist for Bestrophin-3.
Function:
Forms calcium-sensitive chloride channels. Permeable to bicarbonate.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina.
Similarity:
Belongs to the bestrophin family.
SWISS:
Q8N1M1
Gene ID:
144453
Database links:Entrez Gene: 144453 Human
Entrez Gene: 382427 Mouse
Omim: 607337 Human
SwissProt: Q8N1M1 Human
SwissProt: Q6H1V1 Mouse
Unigene: 280782 Human
Unigene: 339322 Mouse
Unigene: 162940 Rat
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