Product Name	TNFAIP8L2
Chinese Name	Tumour坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体
Alias	Tumor necrosis factor alpha-induced protein 8-like protein 2; Inflammation factor protein 20; TIPE2; TIPE 2; TIPE-2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; TNFAIP8L2; TP8L2_HUMAN; Tumor necrosis factor alpha-induced protein 8-like protein 2; AW610835; FLJ23467.
Research Area	Tumour  Cell biology  immunology  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TNFAIP8L2/TIPE2: 10-110/184
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. Subunit: May interact with CASP8; however, such result is unclearsince PubMed:19079267 could not reproduce the interaction withCASP8. Tissue Specificity: Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin Similarity: Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. SWISS: Q6P589 Gene ID: 79626 Database links: Entrez Gene: 79626 Human Entrez Gene: 69769 Mouse Entrez Gene: 100328663 Rabbit Entrez Gene: 310663 Rat Entrez Gene: 510652 Cow Omim: 612112 Human SwissProt: A9X192 Baboon SwissProt: Q3ZBK5 Cow SwissProt: Q6P589 Human SwissProt: Q9D8Y7 Mouse SwissProt: B7NZC7 Rabbit SwissProt: Q6AYJ8 Rat Unigene: 709522 Human
Product Picture	Sample: Huvec(Human) Cell Lysate at 30 ug Primary: Anti-TNFAIP8L2 (SL11035R) at 1/500 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 21 kD Observed band size: 21 kD

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