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Product Name FAM62B Chinese Name 延伸突触蛋白2抗体 Alias Chr2 synaptotagmin; CHR2SYT; E Syt2; ESYT 2; ESYT2; Extended synaptotagmin 2; Extended synaptotagmin like protein 2; FAM 62B antibody Family with sequence similarity 62 (C2 domain containing) member B; Family with sequence similarity 62 member B; KIAA1228; Protein FAM62B; ESYT2_HUMAN. literatures Specific References (1) | SL11003R has been referenced in 1 publications.[IF=14.808] Xue Gong. et al. Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. J Clin Invest. 2021 Dec 15;131(24):e147031 WB ; Human,Mouse.Research Area Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 102kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ESYT2/FAM62B: 801-921/921 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy. The FAM62A gene product has been provisionally designated FAM62A pending further characterization.
Function:
May play a role as calcium-regulated intrinsic membrane protein.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Tissue Specificity:
Widely expressed with high level in cerebellum.
Similarity:
Belongs to the extended synaptotagmin family.
Contains 3 C2 domains.
SWISS:
A0FGR8
Gene ID:
57488
Database links:Entrez Gene: 57488 Human
SwissProt: A0FGR8 Human
Unigene: 490795 Human
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