Product Name	HDGF
Chinese Name	肝癌衍生生长因子/高迁移率族蛋白1样蛋白2抗体
Alias	HDGF; HDGF_HUMAN; Hepatoma derived growth factor; Hepatoma-derived growth factor; High mobility group protein 1 like 2; High mobility group protein 1-like 2; HMG-1L2; HMG1L2.
Research Area	Tumour  Cell biology  immunology  TumourCell biologyMaker
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Pig, Cow, Guinea Pig, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HDGF: 81-180/240
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] Function: Heparin-binding protein, with mitogenic activity for fibroblasts. Acts as a transcriptional repressor. Subunit: Monomer, and domain-swapped homodimer. Subcellular Location: Cytoplasm. Nucleus. Tissue Specificity: Ubiquitous. Post-translational modifications: Sumoylated by SUMO1. Sumoylation prevents binding to chromatin. Similarity: Belongs to the HDGF family. Contains 1 PWWP domain. SWISS: P51858 Gene ID: 3068 Database links: Entrez Gene: 3068 Human Entrez Gene: 15191 Mouse Entrez Gene: 114499 Rat Omim: 600339 Human SwissProt: P51858 Human SwissProt: P51859 Mouse SwissProt: Q8VHK7 Rat Unigene: 506748 Human Unigene: 292208 Mouse Unigene: 860 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (HDGF) Polyclonal Antibody, Unconjugated (SL10956R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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