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Product Name FABP6 Chinese Name 回肠脂肪酸Binding protein抗体 Alias Fatty acid binding protein 6, ileal (gastrotropin); Gastrotropin; GT antibody I 15P; I BABP; I BALB; I BAP; I15P; IBABP; IBALB; IBAPv ILBP; ILBP3; Ileal lipid binding protein; ILLBP; Intestinal 15 kDa protein; Intestinal bile acid binding protein; FABP6_HUMAN. literatures Specific References (1) | SL10931R has been referenced in 1 publications.[IF=1.966] Zhang Y et al. High expression of FABP4 and FABP6 in patients with colorectal cancer. World J Surg Oncol. 2019 Oct 24;17(1):171. IHC-P&WB ; Human.Research Area Tumour Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 14kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FABP6: 61-128/128 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes the ileal fatty acid binding protein. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABP6 and FABP1 (the liver fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. Transcript variants generated by alternate transcription promoters and/or alternate splicing have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Ileal protein which stimulates gastric acid and pepsinogen secretion. Seems to be able to bind to bile salts and bilirubins. Isoform 2 is essential for the survival of colon cancer cells to bile acid-induced apoptosis.
Subcellular Location:
Cytoplasm and Cytoplasm. Localized close to nucleus on the apical side of both normal and neoplastic cells
Tissue Specificity:
Isoform 2 is expressed in colorectal adenocarcinomas and their adjacent normal mucosa (at protein level). Isoform 1 is expressed in the jejunum, ileum, cecum and ascending colon intestine. Isoform 2 is expressed in the gallbladder, duodenum, jejunum, ileum, cecum, ascending, transverse and descending colon, sigmoid colon and rectum.
Similarity:
Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
SWISS:
P51161
Gene ID:
2172
Database links:Entrez Gene: 2172 Human
Entrez Gene: 16204 Mouse
Omim: 600422 Human
SwissProt: P51161 Human
SwissProt: P51162 Mouse
Unigene: 519719 Human
Unigene: 142716 Mouse
Unigene: 10008 Rat
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