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Product Name GPR24 Chinese Name G protein-coupled receptor24抗体 Alias MCHR; G protein coupled receptor 24; GPCR MCH1; GPCR SLC/MCH1; MCH receptor 1; MCH1R; Melanin concentrating hormone receptor 1; SLC-1; Somatostatin receptor like protein; MCHR1_HUMAN. Research Area Cell biology Neurobiology G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 46kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPR24: 2-100/422 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail MCHR, a member of the G protein coupled receptor family 1, is an integral plasma membrane protein which binds melanin concentrating hormone. MCHR can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, MCHR does not seem to bind somatostatin.
Function:
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
Subunit:
Interacts with NCDN.
Subcellular Location:
Cell Membrane; multi-pass membrane protein
Tissue Specificity:
Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
SWISS:
Q99705
Gene ID:
2847
Database links:Entrez Gene: 2847 Human
Entrez Gene: 207911 Mouse
Omim: 601751 Human
SwissProt: Q99705 Human
SwissProt: Q8JZL2 Mouse
Unigene: 248122 Human
Unigene: 323523 Mouse
Unigene: 10822 Rat
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