Product Name	NR2D
Chinese Name	谷氨酸受体2D抗体
Alias	Glutamate [NMDA] receptor subunit epsilon 4; Grin2d; N-methyl D-aspartate receptor subtype 2D; NMDAR2D; NMDE4; NR2D; NMDE4_HUMAN; Glutamate [NMDA] receptor subunit epsilon-4; EB11.
literatures	Specific References  (1)     |     SL1072R has been referenced in 1 publications. [IF=2.48] Liao et al. N-Methyl-D-aspartate Receptor Excessive Activation Inhibited Fetal Rat Lung Development In Vivo and In Vitro. (2016) Biomed.Res.Int. 2016:5843981  WB ;  Rat.   PubMed:27478831
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 Flow-Cyt=3ug/test （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	143kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NR2D: 601-600/1336 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	NR2D is a NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2D is expressed in the brain; it is detected in embryonic stages, peaks at postnatal day 7, and decreases thereafter to adult levels. [FUNCTION] NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. [SUBUNIT] Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Interacts with PDZ domains of INADL and DLG4. [SUBCELLULAR LOCATION] Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. [TISSUE SPECIFICITY] Expressed in brain, mainly in the subcortical region. [SIMILARITY] Belongs to the glutamate-gated ion channel. Subunit: Interacts with PDZ domains of INADL and DLG4 (By similarity). Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Subcellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Similarity: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. SWISS: O15399 Gene ID: 2906 Database links: Entrez Gene: 2906 Human Entrez Gene: 14814 Mouse Entrez Gene: 24412 Rat Omim: 602717 Human SwissProt: O15399 Human SwissProt: Q03391 Mouse SwissProt: Q62645 Rat Unigene: 445015 Human Unigene: 91209 Rat 谷氨酸受体2D（NR2D 又称作Glutamate Receptor NMDAR2D;Glutamate receptor；N-Methyl-d-Asprtate receptor-2D）是脊椎动物中枢神经系统兴奋型神经传递的主要介质。在突触可塑性极大脑学习及记忆功能方面起关键作用。
Product Picture	Blank control: A549. Primary Antibody (green line): Rabbit Anti-NR2D antibody (SL1072R) Dilution: 3μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 3μg /test. Protocol The cells were incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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