Product Name	NPY1R
Chinese Name	神经肽Y1受体抗体
Alias	neuropeptide Y1 receptor; Npy1r; neuropeptide Y receptor Y1; MGC109393; NPY-1; NPY1R_HUMAN.
literatures	Specific References  (3)     |     SL1070R has been referenced in 3 publications. [IF=5.711] Kang X et al. Neuropeptide Y Acts Directly on Cartilage Homeostasis and Exacerbates Progression of Osteoarthritis through NPY2R. J Bone Miner Res. 2020 Feb 26.  IHC,WB ;  mouse.   PubMed:32101625 [IF=5.682] Tüfekci, Kıymet Kübra. et al. A Maternal High-Fat Diet Causes Anxiety-Related Behaviors by Altering Neuropeptide Y1 Receptor and Hippocampal Volumes in Rat Offspring: the Potential Effect of N-Acetylcysteine. MOL NEUROBIOL. 2022 Dec;:1-16  IHC ;  Rat.   PubMed:36502431 [IF=0] 朱镕鑫, et al. "Ghrelin 信号通路在有氧运动对高胆固醇血症小鼠心肌损伤保护中的作用."  WB ;  Mouse.   PubMed:中国科技论文在线
Research Area	Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Pig, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	44kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NPY1R: 301-382/382
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian nervous system and exhibits a diverse range of important physiologic activities, including effects on psychomotor activity, food intake, regulation of central endocrine secretion, and potent vasoactive effects on the cardiovascular system. There are two major subtypes of NPY (Y1 and Y2). The NPY Y1 receptors have been identified in a variety of tissues, including brain, spleen, small intestine, kidney, testis, placenta, breast, colon, ganglion, heart, and aortic smooth muscle. The Y2 receptor is found mainly in the central nervous system. NPY receptors are a member of the G protein-coupled receptor superfamily. Function: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is NPY > [Pro-34] PYY, PYY and [Leu-31, Pro-34] NPY > NPY (2-36) > [Ile-31, Gln-34] PP and PYY (3-36) > PP > NPY free acid. Subcellular Location: Cell membrane. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P25929 Gene ID: 4886 Database links: Entrez Gene: 4886 Human Entrez Gene: 18166 Mouse Entrez Gene: 29358 Rat Omim: 162641 Human SwissProt: P25929 Human SwissProt: Q04573 Mouse SwissProt: P21555 Rat Unigene: 519057 Human Unigene: 5112 Mouse Unigene: 11642 Rat
Product Picture	Sample: Lane 1: Mouse NIH/3T3 tissue lysates Lane 2: Rat Cerebrum tissue lysates Lane 3: Rat Kidney tissue lysates Lane 4: Human 293T cell lysates Primary: Anti-NPY1R (SL1070R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 44 kDa Observed band size: 60 kDa Tissue/cell: rat myocardium tissue;4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-NPY1R Polyclonal Antibody, Unconjugated(SL1070R) 1:400, overnight at 4°C; The secondary antibody was Goat Anti-Rabbit IgG, PE conjugated(SL0295G-PE)used at 1:200 dilution for 40 minutes at 37°C. DAPI(5ug/ml,blue,C-0033) was used to stain the cell nuclei

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