Product Name	HS6ST1
Chinese Name	硫酸乙酰肝素6脑苷脂转硫酸酶1抗体
Alias	6OST 1; 6OST1; DKFZp547H098; FLJ25392; H6 ST1; H6ST 1; H6ST1_HUMAN; Heparan sulfate 6 O sulfotransferase 1; Heparan sulfate 6 sulfotransferase; Heparan sulphate 6 O sulphotransferase 1; Heparan-sulfate 6-O-sulfotransferase 1; HS6 ST1; HS6ST 1; HS6ST ; HS6ST-1; HS6ST1; MGC116899; MGC116901.
literatures	Specific References  (1)     |     SL10701R has been referenced in 1 publications. [IF=7.73] Kodai Suzukiet al. Recombinant thrombomodulin protects against LPS‐induced acute respiratory distress syndrome via preservation of pulmonary endothelial glycocalyx. Br J Pharmacol . 2020 Sep;177(17):4021-4033.  IHC ;  mouse.   PubMed:32497259
Research Area	Cell biology  Neurobiology  Signal transduction  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	48kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HS6ST1: 311-411/411
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Heparan sulfate structures, which are responsible for executing multiple biologic activities, are generated and regulated by heparan sulfate (HS) biosynthetic enzymes. HS6ST1 (heparan sulfate 6-O-sulfotransferase 1), also known as HS6ST, is a 411 amino acid single-pass type II membrane protein that exists as multiple alternatively spliced isoforms and belongs to the sulfotransferase 6 family. Expressed in fetal brain, HS6ST1 functions as a 6-O-sulfation enzyme that specifically catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the N-sulfoglucosamine residue (GlcNS) HS. HS6ST1 is subject to post-translational N-glycosylation and is encoded by a functional gene on human chromosome 2 and a pseudogene on human chromosome 1 (known as LOC728969). Function: 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Subcellular Location: Membrane; Single-pass type II membrane protein Tissue Specificity: Expressed in fetal brain. Post-translational modifications: N-glycosylated. Similarity: Belongs to the sulfotransferase 6 family. SWISS: O60243 Gene ID: 9394 Database links: Entrez Gene: 9394 Human Entrez Gene: 50785 Mouse Omim: 604846 Human SwissProt: O60243 Human SwissProt: Q9QYK5 Mouse Unigene: 512841 Human Unigene: 213566 Mouse

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