Product Name	SCP3
Chinese Name	胆碱磷酸转移酶1抗体
Alias	SCP3; choline phosphotransferase 1; chpt1; COR 1; COR1; MGC71888; RNASCP3; SCP 3; SCP-3; SPGF4; Sycp 3; Sycp3; SYCP3_HUMAN; Synaptonemal complex protein 3.
literatures	Specific References  (1)     |     SL10660R has been referenced in 1 publications. [IF=6.208] Baohui Yao. et al. Reproductive Suppression Caused by Spermatogenic Arrest: Transcriptomic Evidence from a Non-Social Animal. INT J MOL SCI. 2023 Jan;24(5):4611  IHC ;  Zokor.   PubMed:36902039
Research Area	Cell biology  Chromatin and nuclear signals  Cyclin  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	27kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SYCP3: 151-236/236
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010] Function: Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Has an essential meiotic function in spermatogenesis. May be important for testis development. Required for efficient phosphorylation of HORMAD1 and HORMAD2. Subunit: Interacts with SYCP2. Subcellular Location: Nucleus. Chromosome. Note=In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed. Tissue Specificity: Testis-specific. Post-translational modifications: Phosphorylated. DISEASE: Spermatogenic failure 4 (SPGF4) [MIM:270960]: An infertility disorder characterized by azoospermia, a condition of having no sperm present in the ejaculate. Testicular histology shows arrest of spermatogenesis at the pachytene stage of primary spermatocytes. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the XLR/SYCP3 family. SWISS: Q8IZU3 Gene ID: 50511 Database links: Entrez Gene: 50511 Human Entrez Gene: 20962 Mouse Entrez Gene: 25561 Rat Omim: 604759 Human SwissProt: Q8IZU3 Human SwissProt: P70281 Mouse SwissProt: Q63520 Rat Unigene: 506504 Human Unigene: 297977 Mouse Unigene: 34889 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SCP3) Polyclonal Antibody, Unconjugated (SL10660R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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