Product Name	CYT 19
Chinese Name	甲基转移酶cyt-19抗体
Alias	2310045H08Rik; CYT19; Arsenic (+3 oxidation state) methyltransferase; Arsenite methyltransferase; As3mt; AS3MT_HUMAN; C10ORF32; CYT19; Cyt19 protein; Hypothetical protein C10orf32; Methylarsonite methyltransferase; Methyltransferase cyt19; OTTHUMP00000020384; RP11-753C18.6; S adenosylmethionine arsenic (III) methyltransferase; S-adenosyl-L-methionine:arsenic(III) methyltransferase.
Research Area	Tumour  Cell biology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	42kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CYT 19: 21-120/375
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Formation of methylated metabolites is a critical step in the metabolism of inorganic arsenic. Arsenite methyltransferase (cyt19) is localized to the cytoplasm and operates in the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate which is reduced to methylarsonite. Methylarsonite acts as a substrate and is converted into a much less toxic compound dimethylarsinate. cyt19 is highly expressed in liver. Inherited variation in cyt19 may contribute to variation in arsenic metabolism and possibly arsenic-dependent carcinogenesis in humans. Function: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH. Subcellular Location: Cytoplasm. Similarity: Belongs to the methyltransferase superfamily. SWISS: Q9HBK9 Gene ID: 57412 Database links: Entrez Gene: 57412 Human Entrez Gene: 57344 Mouse Entrez Gene: 140925 Rat Omim: 611806 Human SwissProt: Q9HBK9 Human SwissProt: Q91WU5 Mouse SwissProt: Q8VHT6 Rat Unigene: 720370 Human Unigene: 28566 Mouse Unigene: 95453 Rat
Product Picture	Protein: heart(mouse) lysate at 40ug; Primary: rabbit Anti-CYT 19 (SL10633R) at 1:300; Secondary: HRP conjugated Goat-Anti-rabbit IgG(SL0295G-HRP) at 1: 5000; Predicted band size: 42 kD Observed band size: 42 kD Sample: heart (Mouse) Lysate at 40 ug liver (Mouse) Lysate at 40 ug Primary: Anti-CYT 19 (SL10633R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 42 kD Observed band size: 48 kD

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