Product Name	Troponin I fast + slow skeletal muscle
Chinese Name	骨骼肌快/慢肌肌钙蛋白I抗体
Alias	AMCD2B; DA2B; DKFZp451O223; Fast twitch skeletal muscle troponin I; FSSV; fsTnI; OTTHUMP00000014141; OTTHUMP00000014142; OTTHUMP00000014143; OTTHUMP00000033877; OTTHUMP00000033909; OTTHUMP00000033910; SSTNI; TNN1; Troponin I fast twitch 2; Troponin I type 1 (skeletal, slow); Troponin I type 2 (skeletal, fast); Troponin I, fast skeletal muscle; Troponin I, fast twitch isoform; Troponin I, fast twitch skeletal muscle isoform; Troponin I, skeletal, fast; Troponin I, slow skeletal muscle; Troponin I, slow twitch isoform; TNNI1_HUMAN; TNNI2_HUMAN.
literatures	Specific References  (1)     |     SL10617R has been referenced in 1 publications. [IF=7.525] Ma Manting. et al. LncRNA-TBP mediates TATA-binding protein recruitment to regulate myogenesis and induce slow-twitch myofibers. CELL COMMUN SIGNAL. 2023 Dec;21(1):1-16  WB ;  Chicken.   PubMed:36635672
Research Area	Cell biology  immunology  Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Chicken, Pig, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	33kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human TNNI1+TNNI2 : 51-150/182
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. Function: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Subunit: Binds to actin and tropomyosin. DISEASE: Arthrogryposis, distal, 2B (DA2B) [MIM:601680]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. DA2B is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the troponin I family. SWISS: P19237 Gene ID: 7135 Database links: Entrez Gene: 7135 Human Entrez Gene: 7136 Human Omim: 191042 Human Omim: 191043 Human SwissProt: P19237 Human SwissProt: P48788 Human

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