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Product Name Defensin alpha 5 Chinese Name 防御素α5抗体 Alias alpha 5; alpha 5 Defensin; DEF5; DEF5_HUMAN; DEF5_RAT; Defa; Defa29; DEFA5; Defcr29; Defcr5; Defensin 5; Defensin alpha-5; Defensin alpha 5 Paneth cell specific; Defensin alpha 5 preproprotein; Defensin; Enteric defensin; HD 5; HD5; HD5(20-94); HD5(63-94); MGC129728; RD 5. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 4.1kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Defensin alpha 5: 31-94/94 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.
Function:
Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.
Subcellular Location:
Secreted. Cytoplasmic vesicle, secretory vesicle. Peptides HD5(20-94), HD5(23-94) and HD5(29-94) are found within tissues, HD5(20-94) being the predominant intracellular form. Peptides HD5(56-94) and HD5(63-94) are found in the extracellular milieu, HD5(63-94) being the most abundant form.
Tissue Specificity:
Paneth cells of the small intestine (at protein level).
Post-translational modifications:
Glycosylated.
Similarity:
Belongs to the alpha-defensin family.
SWISS:
Q01523
Gene ID:
1670
Database links:Entrez Gene: 1670 Human
Omim: 600472 Human
SwissProt: Q01523 Human
Unigene: 655233 Human
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