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Product Name Tnni1 Chinese Name 骨骼肌慢肌肌钙蛋白I抗体 Alias Troponin I, slow skeletal muscle; SSTNI; TNN1; TNNI1_MOUSE; Troponin I slow skeletal muscle; Troponin I, slow twitch isoform. literatures Specific References (1) | SL10571R has been referenced in 1 publications.[IF=4.938] Du J et al. The regulation of skeletal muscle fiber-type composition by betaine is associated with NFATc1/MyoD.J Mol Med (Berl). 2018 Jun 6. WB ; Mouse.Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Tnni1: 11-100/187 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008].
Function:
Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
Subunit:
Binds to actin and tropomyosin.
Similarity:
Belongs to the troponin I family.
SWISS:
P19237
Gene ID:
7135
Database links:Entrez Gene: 7135 Human
Entrez Gene: 7136 Human
Entrez Gene: 21952 Mouse
Entrez Gene: 21953 Mouse
Omim: 191042 Human
Omim: 191043 Human
SwissProt: P19237 Human
SwissProt: P48788 Human
SwissProt: P13412 Mouse
SwissProt: Q9WUZ5 Mouse
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